Abstract: In this study,the protective effect of resveratrol on gastric mucosal damage induced by water-immersion restraint stress(WRS) in rats was investigated.30 wistar rats were randomly divided into five experimental groups:control group,model group,low dose resveratrol(Res) group(30 mg/kg),middle dose Res group(60 mg/kg) and high dose Res group(120 mg/kg).Macroscopic gastric lesions were evaluated,the ulceration index and pH of gastric juice was measured,the content of malondialdehyde(MDA) and the activity of super oxide dismutase(SOD) in gastric mucosa were measured.The results showed that resveratrol significantly reduced the ulcer area induced by WRS and inhibited the Ulcer Index.Middle dose Res group showed the best result(P＜0.01);It significantly improved the SOD(P＜001) and pH of gastric juice,while reduced content of MDA(P＜0.01).The present study suggested that resveratrol was able to protect the gastric mucosa which may be mediated by improving the antioxidant live enzyme activity and restricting free radical production during stress.

Key words: resveratrol, stress, ulceration index, malondialdehyde, super oxide dismutase