NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (11): 1767-1770.

• Article • Previous Articles     Next Articles

Lyngbyatoxin A from Deep South China Sea-Derived Streptomyces sp.SCSIO 5604

TANG Gui-ling1,2, HUANG Hong-bo1, WANG Bo1, TIAN Xin-peng1, JU Jian-hua1*, SONG Yong-xiang1*   

  1. 1 Key Laboratory of Tropical Marine Bio-resourses and Ecology,Chinese Academy of Sciences,Research Center for Marine Microbes,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Science,Guangzhou 510301,China; 2 University of Chinese Academy of Sciences,Beijing 100049，China
  • Online:2014-11-29 Published:2014-12-18

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Abstract: The strain SCSIO 5604 was identified to be Streptomyces sp.by 16S rRNA gene sequence,which was isolated from a sediment sample collected in South China Sea at E 120° 0.250′ and N 20° 22.971′ at 3536 m depth.Guided by brine shrimp lethality and HPLC-DAD,chemical analysis of the crude extract of the fermentation culture,led to the isolation of an indolelactam compound,namely lyngbyatoxin A.The structure of lyngbyatoxin A was identified based on the HR-ESI-MS, 1H-NMR,13C-NMR spectra and comparing with literature data.

Key words: marine actinomycete, Streptomyces sp., lyngbyatoxin A, brine shrimp lethality

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