Abstract: This article illustrated the effect of resveratrol (R) on the antioxidation and lymphocyte subsets of obese mice and resistant mice in response to a high-fat diet.Male C57BL/6 mice were randomly assigned to two groups.The control group consumed a normal diet (Control).The experimental group was fed with a high-fat diet (HFD).After 13 weeks,HFD mice were divided by body weight into dietinduced obese (DIO) or diet-resistant (DR) mice and were fed with HFD and HFD + 0.06% R for 13 weeks,respectively.Mice fed with normal diet were set as control group.The body weights,plasma lipid,antioxidant enzyme activities and MDA in spleen were examined.The proportion of lymphocyte subsets were determined by flow cytometry.The experimental results indicated that supplementation of resveratrol can reduce the body weight,decrease plasma lipid and increase the antioxidant capacity of DIO and DR mice.It increased the ratio of CD³⁺CD⁴⁺ to CD³⁺CD⁸⁺ T cell as well as the production of CD⁴⁺CD25⁺FoxP3⁺Tregs of HFD mice,especially in DIO mice,and thus relieved the chronic inflammatory reaction.

Key words: resveratrol, high-fat diet, diet-induced obesity, diet resistance, antioxidation, lymphocyte subsets