Abstract: The effects of dietary supplementation with Astragalus polysaccharides (APS) and grape seed extract (GSE) individually and together on loaded swimming time and blood parameters in aging mice model were investigated in this study.The aging mice model was induced by dietary supplementation with 0.5% Dgalactose.Forty aging mice model were randomly assigned to four treatment groups as aging model control,APS group,GSE group and APS+GSE group with 10 mice in each treatment.APS and GSE both supplemented at the dose of 0.1% of diet.Loaded swimming time and blood parameters were determined on the 42 day and 43 day respectively after the beginning of the experiment.The results showed that the mice had markedly increased loaded swimming time,decreased significantly granulocyte counts and mean corpuscular hemoglobin (MCH) in APS+GSE treatment as compared with aging model control;the mice treated by APS or GSE had significantly decreased red blood cell volume distribution width (RDW),hemoglobin (HGB) and mean corpuscular hemoglobin (MCH).These results suggested that dietary supplementation with APS and GSE can significantly prolong loaded swimming time in aging mice model while individual or simultaneous dietary supplementation with APS and GSE can affect some blood parameters.

Key words: Astragalus polysaccharides, grape seed extract, aging, mice, blood parameters