Abstract: In this study,(+)-balasubramide was totally synthesized by selecting cinnamaldehyde as starting material with asymmetric epoxidation via one-pot reaction,amine-ester interchange and intramolecular cyclization.Natural product (+)-balasubramide was synthesized with a 44% overall yield and excellent enantioselectivity (>99%) and confirmed by 1H NMR, 13C NMR,HR-MS and IR.This paper described a convenient and efficient method for the synthesis of natural (+)-balasubramide and laid a certain foundation for the further study of bioactivity and structure-activity relationships of this compound.

Key words: (+)-balasubramide, cinnamaldehyde, asymmetric catalysis, synthesis