天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (1): 152-158.doi: 10.16333/j.1001-6880.2017.1.029

• 综述 • 上一篇    下一篇

源自海洋真菌的抗肿瘤活性天然产物研究新进展

金黎明1*,徐鑫2,包艳春1   

  1. 1 大连民族大学生命科学学院,大连 116600;2 中国科学院受体结构与功能重点实验室中国科学院上海药物研究所,上海 201203
  • 出版日期:2017-01-31 发布日期:2017-02-17

New Research Progress on Antitumor Natural Products from Marine-derived Fungi

JIN Li-ming1*,XU Xin2,BAO Yan-chun1   

  1. 1 College of Life Science,Dalian Nationalities University,Dalian 116600,China;2The CAS Key Laboratory of Receptor Research,Shanghai Institute of MateriaMedica,Chinese Academy of Sciences,Shanghai 201203,China
  • Online:2017-01-31 Published:2017-02-17

摘要: 近年来,海洋真菌因其能够产生大量结构新颖、活性显著的代谢产物而受到广泛关注,其中许多代谢产物具有较强的抗肿瘤活性。本文按照海洋真菌的来源进行分类,从海洋动物来源真菌、红树林来源真菌、海洋沉积物来源真菌、海藻来源真菌、海水来源真菌等5个方面,综述了2014~2016年4月以来发表的具有抗肿瘤活性的海洋真菌来源的新天然产物,主要介绍天然产物的化学结构和生物活性,为具有抗肿瘤活性的海洋真菌天然产物的进一步研究开发提供参考。

关键词: 海洋真菌, 天然产物, 抗肿瘤活性

Abstract: In recent years,marine natural products of fungal origin have gained considerable recognition,as many of them possess novel structures and interesting biological and pharmacological properties.Many metabolites show antitumor properties.This review partially summarizes the new antitumor compounds from marine fungi with classification according to the sources of marine fungi (marine animals,mangrove,sediment,alga and sea water),including their chemical structures and biological activities.Those fungi found from 2014 to the April 2016 are discussed.This review provides reference for further research of the antitumor natural products from marine-derived fungi.

Key words: marine-derived fungi, natural products, antitumor activities

中图分类号: 

Q939.321