Box-Behnken设计-效应面法优化离子液体提取废次茶叶中咖啡因工艺

doi:10.16333/j.1001-6880.2017.3.023

天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (3): 489-496.doi: 10.16333/j.1001-6880.2017.3.023

Box-Behnken设计-效应面法优化离子液体提取废次茶叶中咖啡因工艺

黄飞1*，徐慧敏1，王杰1，黄涛1，黄成相1，吴孔林2

1 黄山学院化学化工学院，黄山 245041；2安徽师范大学化学与材料科学学院功能性分子固体材料教育部重点实验室，芜湖 241000

出版日期:2017-03-31 发布日期:2017-04-06

Optimization of Ionic Liquids Extraction of Caffeine from the Discarding Tea by Box-Behnken Design and Response Surface Analysis

HUANG Fei1*,XU Hui-min1,WANG Jie1,HUANG Tao1,HUANG Cheng-xiang1,WU Kong-lin2

1 College of Chemistry and Chemical Engineering,Huangshan University,Huangshan 245041,China;2College of Chemistry and Materials Science,The Key Laboratory of Functional Molecular Solids, Ministry of Education,Anhui Normal University,Wuhu 241000,China

Online:2017-03-31 Published:2017-04-06

摘要/Abstract

摘要： 以咖啡因的提取率为评价指标，在单因素实验基础上，通过Box-Behnken设计-效应面法考察料液比、浸提时间、浸提温度、离子液体［HSO₃-pmim］+［HSO₄］浓度4个因素对咖啡因提取率的影响。实验结果表明，离子液体［HSO₃-pmim］+［HSO₄］-提取咖啡因的最优提取工艺为：料液比为0.05 g/mL，浸提时间为160 min，浸提温度为90 ℃，离子液体浓度为70%，咖啡因的提取率为95.1 mg/5 g茶样。Box-Behnken设计-效应面法优化离子液体［HSO₃-pmim］+［HSO₄］-提取废次茶叶中咖啡因，提取工艺合理，方法简便，精确度高，可预测性好。

关键词: Box-Behnken设计-效应面法, 离子液体［HSO₃-pmim］+［HSO₄］-, 废次茶叶, 咖啡因

Abstract: With extraction yield of caffeine as evaluation index,the effects of liquid-solid ratio,extraction temperature,extraction time,concentration of ionic liquids ［HSO₃-pmim］+［HSO₄］- were investigated through Box-Behnken design and response surface methodology based on single factor experiment.The results suggested that the optimal conditions of extraction technology were as follows:liquid-solid ratio was 0.05 g/mL,extraction time was 160 min,extraction temperature was 90 ℃,ionic liquids［HSO₃-pmim］+［HSO₄］^- concentration was 70%.Under these conditions the extraction yield of caffeine was 95.1 mg/ 5g tea sample.The optimized extraction technology was reasonable,simple,precise and with good predictability.

Key words: Box-Behnken design and response surface methodology, ionic liquids［HSO₃-pmim］+［HSO₄］-, discarding tea, caffeine

中图分类号:

TQ914.4

黄飞1*，徐慧敏1，王杰1，黄涛1，黄成相1，吴孔林2. Box-Behnken设计-效应面法优化离子液体提取废次茶叶中咖啡因工艺[J]. 天然产物研究与开发, 2017, 29(3): 489-496.

HUANG Fei1*,XU Hui-min1,WANG Jie1,HUANG Tao1,HUANG Cheng-xiang1,WU Kong-lin2. Optimization of Ionic Liquids Extraction of Caffeine from the Discarding Tea by Box-Behnken Design and Response Surface Analysis[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2017, 29(3): 489-496.

Box-Behnken设计-效应面法优化离子液体提取废次茶叶中咖啡因工艺

Optimization of Ionic Liquids Extraction of Caffeine from the Discarding Tea by Box-Behnken Design and Response Surface Analysis

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