天然产物研究与开发 ›› 2022, Vol. 34 ›› Issue (7): 1261-1271.doi: 10.16333/j.1001-6880.2022.7.019

• 综述 • 上一篇    

肠道微生物代谢苷类化合物的研究进展

谢果珍1，黄莉莉1，张水寒2，谭周进1*   

  1. 1湖南中医药大学，长沙 410208；2湖南省中医药研究院中药研究所，长沙 410013
  • 出版日期:2022-07-28 发布日期:2022-07-25
  • 基金资助:
    国家自然科学基金（81804076）；湖南省自然科学基金（2020JJ5426）

Advances in metabolism of glycosides by gut microbiota 

XIE Guo-zhen1,HUANG Li-li1,ZHANG Shui-han2,TAN Zhou-jin1*   

  1. 1Hunan University of Chinese Medicine,Changsha 410208,China; 2Institute of Chinese Materia Medica,Hunan Academy of Chinese Medicine,Changsha 410013,China
  • Online:2022-07-28 Published:2022-07-25

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摘要： 肠道微生物对苷类化合物的体内代谢十分重要，可分泌代谢酶进行脱糖基、脱甲基、脱羟基、水解和氧化还原等反应将苷代谢生成次级苷、苷元或其他代谢产物，从而促进苷类药物的吸收并发挥药效。本文论述了肠道微生物及代谢酶对苷类化合物代谢的意义，总结了肠道微生物对不同结构类型的苷类化合物的代谢规律及代谢产物，为了解苷类药物的疗效基础、作用机理及利用微生物转化开发苷类药物提供参考。

关键词: 肠道微生物, 苷类化合物, 代谢, 酶

Abstract:

Gut microbiota is essential in the metabolism of glycosides in vivo.It is open to metabolism by metabolic enzymes,through deglycosylation,demethylation,dehydroxylation,hydrolysis and other reactions.It is generally believed that glycosides are converted to the corresponding aglycones,secondary glycosides,or other metabolites by the gut microbiota and/or by the metabolic enzymes,and as such absorbed from the small intestine.In this review,we summarize our existing knowledge of the rules underlying the metabolic regulation of gut microbiota in different types of glycosides.The significance of gut microbiota and metabolic enzymes on the glycoside metabolism is also discussed.This paper provides a basis for the understanding of the therapeutic basis and mechanism of glycosides,and development of new drugs by microbial transformation.

Key words: gut microbiota, glycosides, metabolism, enzymes

中图分类号:  R932

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