天然产物研究与开发 ›› 2023, Vol. 35 ›› Issue (3): 519-530.doi: 10.16333/j.1001-6880.2023.3.018

• 综述 • 上一篇    下一篇

黄精多糖结构特征及其生物活性研究进展

田   磊1，柳春燕1,2,3,4，韩   军1,2,3，王国栋1,2,3,4*   

  1. 1皖南医学院药学院 药物研发中心；2安徽省多糖药物工程技术研究中心；3安徽省皖南地区植物药活性物质筛选与再评价工程实验室；4活性生物大分子研究安徽省重点实验室，芜湖241002
  • 出版日期:2023-03-28 发布日期:2023-03-28
  • 基金资助:
    安徽省高校自然科学研究重大项目（KJ2019ZD32，KJ 2021ZD0101）；安徽省教育厅高校学科（专业）拔尖人才学术资助项目（gxbjZD2022043）；芜湖市科技项目（2022cg20）

Progress on the structural characteristic and biological activity of Polygonati Rhizoma polysaccharides

TIAN Lei1,LIU Chun-yan1,2,3,4,HAN Jun1,2,3,WANG Guo-dong1,2,3,4*   

  1. 1Drug Research & Development Center,School of Pharmacy,Wannan Medical College;2Anhui Provincial Engineering Research Center for Polysaccharide Drugs;3Anhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicine in Southern Anhui;4Anhui Province Key Laboratory of Active Biological Macromolecules,Wuhu 241002,China
  • Online:2023-03-28 Published:2023-03-28

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摘要： 中药黄精为百合科黄精属植物黄精（Polygonatum sibiricum Delar.ex Redoute）、滇黄精（Polygonatum kingianum Coll.et Hemsl）与多花黄精（Polygonatum cyrtonema Hua）的干燥根茎，具有悠久的药用历史。黄精多糖是黄精中最重要的活性化合物之一，具有抗氧化、调节免疫、抗肿瘤、抗骨质疏松、降血糖、降血脂和抗动脉粥样硬化等多种生物活性，已经成为黄精开发应用研究的热点。本文综述了近年来国内外对黄精多糖的结构特征、生物活性及其相关机制的研究进展，以期为黄精多糖的深入研究与开发提供理论参考。

关键词: 黄精, 多糖, 结构特征, 生物活性, 作用机制

Abstract:

The Chinese herb Polygonati Rhizoma,which is the dried rhizome of Polygonatum sibiricum Delar.ex Redoute,Polygonatum kingianum Coll.et Hemsl and Polygonatum cyrtonema Hua in genus Polygonatum,family Liliaceae,has a long history of medicinal use.The Polygonati Rhizoma polysaccharide is one of the most important active compounds in Polygonati Rhizoma,which has various biological activities such as antioxidant,immune modulation,anti-tumor,anti-osteoporosis,hypoglycemic,hypolipidemic and anti-atherosclerosis effects,etc.It has become a hot spot for the development and application research of Polygonati Rhizoma.In this article,the recent domestic and foreign literatures on the structural characteristics,biological activities and action mechanisms of Polygonati Rhizoma polysaccharides were summarized,which provide some reference for the in-depth research and development of Polygonati Rhizoma.

Key words: Polygonati Rhizoma, polysaccharide, structural characteristics, biological activity, mechanism of action

中图分类号:  R282.71 R285

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