Network pharmacology and molecular docking were used to predict the potential targeting mechanism of invigorating qi,warming yang,promoting blood circulation and inducing diuresis in the combination of traditional Chinese medicine components for the prevention and treatment of chronic heart failure (CHF).Through literature retrieval and preliminary experience of the research group,Astragali Radix,Cinnamomi Ramulus,Salviae Miltiorrhizae Radix,Lepidii Semen were identified as four representative drugs for invigorating qi,warming yang,promoting blood circulation and inducing diuresis.TCMSP and Batman-TCM platforms were used to screen the active ingredients of the four drugs and predict the relevant targets of action targets;CHF-related targets were screened by GeneCards,OMIM and TTD databases;Protein interaction PPI network was constructed by String database;GO analysis and KEGG pathway analysis were performed using DAVID database;Cytoscape 3.8.0 software was used to construct the network diagram;Molecular docking was performed by Autodock Vina.A total of 21 compounds and 10 759 CHF targets were collected,including 75,56,163,27 intersection targets of Astragalus saponins,total salvianolic acid,aqueous extract from Lepidii Semen,cinnamaldehyde with disease,and 40 core targets were screened according to degree value;GO analysis and KEGG pathway analysis visualized the top items respectively;molecular docking results showed that the four The molecular docking results showed that the active ingredients of the Chinese medicines could bind to the core targets stably.The results of animal experiments showed that the component compatibility could improve cardiac function,reduce B type natriuretic peptide precursor(NT-proBNP) and cardiac troponin I(cTnI) in plasma,increase superoxide dismutase (SOD) in serum,decrease malondialdehyde (MDA),and improve cardiomyocyte apoptosis.This study reveals the mechanism of multi-component,multi-target,multi-pathway therapy for CHF combined with Astragalus saponins,total salvianolic acid,cinnamaldehyde and aqueous extract from Lepidii Semen,which may be related to apoptosis,oxidative stress,inflammatory response and energy metabolism.