天然产物研究与开发 ›› 2024, Vol. 36 ›› Issue (3): 485-498.doi: 10.16333/j.1001-6880.2024.3.012

• 开发研究 • 上一篇    下一篇

基于炮制前后质量一致性的清半夏炮制新工艺评价

颜雨豪,殷莉丽,黎   智,蒋孟莲,杨转珍,万子玉,赖月月,李   敏*   

  1. 成都中医药大学 药学院/现代中药产业学院 省部共建西南特色中药资源国家重点实验室,成都611137
  • 出版日期:2024-03-20 发布日期:2024-03-20
  • 基金资助:
    四川省科技厅科技项目(2021ZHCG0067)

Evaluation of new processing technology of Pinelliae Rhizoma Praeparatum cum Alumine based on quality consistency before and after processing

YAN Yu-hao,YIN Li-li,LI Zhi,JIANG Meng-lian,YANG Zhuan-zhen,WAN Zi-yu,LAI Yue-yue,LI Min*   

  1. State Key Laboratory of Characteristic Chinese Drug Resource in Southwest China,School of Pharmacy/School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China
  • Online:2024-03-20 Published:2024-03-20

摘要: 为研究半夏与清半夏的质量传递关系,并评价新工艺蒸法所得炮制品与清半夏的质量一致性,本研究检测了生半夏及3种炮制品的浸出物、有机酸、多糖、核苷、蛋白质含量,使用主成分分析等方法比较3种炮制品的差异。结果表明,与生半夏相比,浸、煮制清半夏的浸出物减少,而蒸制品浸出物增加了264.76%;总酸、多糖含量均显著增加,其中蒸制品的增幅最大;核苷、蛋白质含量均大幅降低;综合分析方法均表明蒸制品与传统方法所得清半夏存在较大的质量差异。由此可知,浸、煮制清半夏质量一致性较好,而蒸法炮制品仍需对其加工工艺、药效做进一步研究。

关键词: 半夏, 清半夏, 炮制工艺, 质量传递, 主成分分析, 一致性

Abstract:

To investigate the quality transfer relationship between Pinellia Rhizoma (PR) and Pinelliae Rhizoma Praeparatum cum Alumine (PRPA),as well as to assess the consistency in quality between the newly processed product using steam processing and PRPA,this study examined the leachate,organic acids,polysaccharides,nucleosides,and protein content of raw PR and three processed products.Differences among the three processed products were compared using methods such as principal component analysis.The results indicated notable differences in quality between the steamed product and traditional concoctions of PR.Compared to raw PR,the extracts from soaking and boiling decreased,while the extract from steaming increased by 264.76%.Total organic acid and polysaccharide content significantly increased,especially in the steamed product.Nucleoside and protein content,however,experienced substantial reduction.Hence,it can be inferred that the quality consistency of soaked and boiled PRPA is relatively high,while further research is needed to explore the processing techniques and medicinal effects of the steamed products.

Key words:

中图分类号:  R283.3