海洋链霉菌Streptomyces sp.SCSIO1667中吲哚咔唑生物碱类成分的研究

天然产物研究与开发 ›› 2011, Vol. 23 ›› Issue (3): 415-419.

海洋链霉菌Streptomyces sp.SCSIO1667中吲哚咔唑生物碱类成分的研究

周俊勇¹，黄洪波^2,3,4，汪中文^2,3,4，杨民和¹，田新朋^2,3,4，张偲^2,3,4，张长生^2,3,4，鞠建华^2,3,4*

1福建师范大学生命科学学院，福州350108；2中国科学院海洋生物资源可持续利用重点实验；3广东省海洋药物重点实验室；4中国科学院海洋微生物中心中国科学院南海海洋研究所，广州 510301

收稿日期:2011-08-03 出版日期:2011-06-25 发布日期:2011-08-08
通讯作者: jju@scsio.ac.cn
基金资助:
中国科学院知识创新工程重要方向项目(KSCX2-YW-G-065,KZCX2-YW-JC202,KSCX2-YW-G-073)；中国科学院南海海洋所领域前沿项目(LYQY200805)

Metabolites of Indolocarbazole Alkloids from the Marine-derived Streptomyces sp.SCSIO 1667

ZHOU Jun-yong1, HUANG Hong-bo2,3,4, WANG Zhong-wen2,3,4, YANG Min-he1, TIAN Xin-peng2,3,4, ZHANG Si2,3,4, ZHANG Chang-sheng2,3,4, JU Jian-hua2,3,4*

1College of life sciences,Fujian Normal University,Fuzhou 350108; 2Key Laboratory of Marine Bio-resourses Sustainable Utilization; 3Guangdong Key laboratory of Marine Materia Medica; 4Research Center for Marine Microbes,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China

Received:2011-08-03 Online:2011-06-25 Published:2011-08-08

摘要/Abstract

摘要：

运用大孔树脂柱及硅胶柱层析对南海海洋链霉菌Streptomyces sp.SCSIO 1667的代谢产物进行了研究，从SCSIO 1667菌株的发酵产物中分离得到两个indolocarbazole生物碱类化合物，经质谱，1D、2D NMR波谱数据分析鉴定为星形孢菌素（staurosporine，1）和K-252d（2）。

关键词: 海洋放线菌, Streptomyces sp.SCSIO 1667, staurosporine, K-252d

Abstract:

Two indolocarbazole alkloids,staurosporine（1）and K-252d（2）were isolated from the culture of strain SCSIO 1667 by resin column chromatography and repeated silica gel column chromatography.The structures of the two compounds were identified on the basis of spectroscopic (MS; 1H,13C,COSY,HMQC and HMBC NMR) data analyses.

Key words: marine actinomycetes, Streptomyces sp.SCSIO 1667, staurosporine, K-252d

中图分类号:

Q939.13 R931.77

周俊勇，黄洪波，汪中文，杨民和，田新朋，张偲，张长生，鞠建华. 海洋链霉菌Streptomyces sp.SCSIO1667中吲哚咔唑生物碱类成分的研究[J]. 天然产物研究与开发, 2011, 23(3): 415-419.

ZHOU Jun-yong, HUANG Hong-bo, WANG Zhong-wen, et al.. Metabolites of Indolocarbazole Alkloids from the Marine-derived Streptomyces sp.SCSIO 1667[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(3): 415-419.

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