天然产物研究与开发 ›› 2025, Vol. 37 ›› Issue (12): 2240-2247.doi: 10.16333/j.1001-6880.2025.12.007 cstr: 32307.14.1001-6880.2025.12.007

• 研究简报 • 上一篇    下一篇

滇黄精根茎中1个新的异螺甾烷醇型皂苷

鲍泥满，郝俊杰，张晓东，叶浩敏，邱  斌*，俞  捷*   

  1. 云南中医药大学中药学院，昆明 650500
  • 出版日期:2025-12-30 发布日期:2025-12-29
  • 基金资助:
    国家自然科学基金（82174037）；云南省科技厅中医联合项目面上项目（202101AZ070001-051，202301AZ070 001-056）；云南省重大科技专项计划（202102AA310045）

A new isospirostanol saponin from the rhizomes of Polygonatum kingianum

BAO Ni-man,HAO Jun-jie,ZHANG Xiao-dong，YE Hao-min,QIU Bin*,YU Jie*   

  1. School of Chinese Materia Medica，Yunnan University of Chinese Medicine，Kunming 650500，China
  • Online:2025-12-30 Published:2025-12-29

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摘要：

研究滇黄精（Polygonatum kingianum）根茎的化学成分。利用硅胶、Sephadex LH-20葡聚糖凝胶、大孔树脂等柱色谱，结合半制备型HPLC技术从滇黄精根茎的醇提物中分离纯化得到14个化合物，通过波谱学数据鉴定了化合物的结构，分别为(25S)-kingianoside Z1（1）、(25R)-kingianoside G（2）、菝葜皂苷元（3）、异菝葜皂苷元（4）、2-乙酰基β-蜕皮甾酮（5）、β-蜕皮甾酮（6）、polygonatone H（7）、4′,5,7-trihydroxy-6,8-dimethylhomoisoflavanone（8）、disporopsin（9）、5,7-dihydroxy-6-methyl-3-(2′,4′ -dihydroxybenzyl)-chroman-4-one（10）、新甘草苷（11）、4′-demethylleucomin-7-O-β-D-gluco-pyranoside（12）、异甘草素（13）、(+)-syringaresinol（14）。化合物1为新的异螺甾烷醇型皂苷，化合物4、5、6、7、8、10、12和14首次从该植物中分离得到。

关键词: 滇黄精, 异螺甾烷醇型皂苷, (25S)-kingianoside Z1, 菝葜皂苷元, 新甘草苷, disporopsin

Abstract:

This study aims to investigate the chemical consituents from Polygonatum kingianum. The ethanol extract from the rhizomes of P. kingianum were isolated and purified by silica gel, ODS, Sephadex LH-20 column chromatography and semi-preparative HPLC. The structures of isolated compounds were elucidated by spectral techniques and comparison with literature data. Fourteen compounds were obtained and identified as (25S) -kingianoside Z1 (1), (25R)-kingianoside G (2), sarsasapogenin (3), smilagenin (4), 20-hydroxyecdysone-2-acetate (5), 20-hydroxyecdysone (6), polygonatone H (7), 4′,5,7-trihydroxy-6,8-dimethylhomoisoflavanone (8), disporopsin (9), 5,7-dihydroxy-6-methyl-3-(2′,4′-dihydroxybenzyl)-chroman-4-one (10), neoliquiritin (11), 4′-demethylleucomin-7-O-β-D-glucopyranoside (12), isoliquiritigenin (13), (+)-syringaresinol (14). It should be pointed out that compound 1 is a new isospirostanol saponin，and compounds 4, 5, 6, 7, 8, 10, 12, 14 were obtained from the Polygonatum kingianum for the first time.

Key words: Polygonatum kingianum, isospirostanol saponin, (25S)-kingianoside Z1, sarsasapogenin, neoliquiritin, disporopsin

中图分类号:  R284

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