天然产物研究与开发 ›› 2020, Vol. 32 ›› Issue (增刊1): 32-37.doi: 1001-6880(2020)Suppl-0026-06

• 研究论文 • 上一篇    下一篇

野生三叶青对幼龄大鼠的解热作用研究

胡孙源，潘口口，杨洪飞，陈玲，龚战，杨元宵*   

  1. 杭州医学院，杭州 310053

  • 出版日期:2020-06-28 发布日期:2020-07-20
  • 基金资助:
    国家级创新训练项目（201813023011）

Study on the antipyretic effect of wild Tetrastigmae Radix on febrile immature rats

  1. HU Sun-yuan,PAN Kou-kou,YANG Hong-fei,CHEN Ling,GONG Zhan,YANG Yuan-xiao*

  • Online:2020-06-28 Published:2020-07-20

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43

摘要：

本实验采用LPS致热模型，观察野生三叶青水煎液对发热大鼠肛温，血浆白细胞、中性粒细胞、淋巴细胞、单核细胞数及百分比以及血清IL-6、PCT、CRP及IL-10水平的影响。实验结果表明，与正常对照组相比，20 μg/kg LPS刺激2.5 h后，幼龄大鼠肛温显著升高（P<0.01）。给予三叶青水煎液后，与LPS模型组相比，5 g/kg、10 g/kg三叶青均能显著降低幼龄大鼠的肛温（P<0.01）、白细胞数（P<0.01）、嗜中性粒细胞数及百分比（P<0.01）、单核细胞数（P<0.01）及百分比（P<0.05，P<0.01），显著升高淋巴细胞数（P<0.05）及百分比（P<0.01）；显著降低大鼠血液中IL-6含量及CRP水平（P<0.05，P<0.01）、PCT含量（P<0.05）；10 g/kg三叶青显著增加大鼠血液中IL-10含量（P<0.05）。结果说明野生三叶青对幼龄大鼠具有较好的解热抗炎作用。

关键词: 野生三叶青, 水煎液, LPS, 解热, 抗炎, 幼龄大鼠

Abstract:

In this study,LPS thermogenic model was used to observe the effects of decoction of wild Tetrasfigmae Radix(DWTR) on anal temperature,number and percentage of plasma leukocytes,neutrophils,lymphocytes and monocytes,as well as serum IL-6,PCT,CRP and IL-10 levels in febrile immature rats.The results showed that compared with the normal control group,the body temperature of immature rats increased significantly after 20 μg/kg LPS stimulation for 2.5 hours (P<0.01).Compared with LPS model group,5 and 10 g/kg DWTR could significantly reduce the body temperature of febrile immature rats (P<0.01).It can significantly reduce the number of white blood cells (P<0.01),the number and percentage of neutrophils (P<0.01),the number of monocytes (P<0.01) and its percentage (P<0.05,P<0.01),and significantly increase the number of lymphocytes (P<0.05) and its percentage (P<0.01).Serum IL-6 content (P<0.05,P<0.01),CRP level (P<0.05,P<0.01) and PCT content (P<0.05) were significantly reduced in immature rats;10 g/kg can improve the level of IL-10 in immature rats (P<0.05).It shows that DWTR has good antipyretic and anti-inflammatory effects on immature rats.

Key words: wild Tetrastigmae Radix, decoction, LPS, antipyretic, anti-inflammatory, immature rat

中图分类号:  R285

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