天然产物研究与开发 ›› 2023, Vol. 35 ›› Issue (增刊2): 154-163.

• 综述 • 上一篇    下一篇

水飞蓟宾的植物来源、提取方法和抗癌活性研究进展

刘婷婷*   

  1. 广州科技职业技术大学,广州 510000
  • 出版日期:2023-12-27 发布日期:2023-12-12
  • 基金资助:
    2022年度广州科技职业技术大学校级课题(2022ZR01)

Research progress on plant origin,extraction method and anti-cancer activity of silybin

LIU Ting-ting*   

  1. Guangzhou Vocational University of Science and Technology,Guangzhou 510000,China
  • Online:2023-12-27 Published:2023-12-12

摘要: 水飞蓟宾是一种黄酮类化合物,常见于多种植物中。天然产物研究者很久之前就开始不断优化水飞蓟宾的纯化制备工艺,通常,将脱脂处理过的植物原料再用于提取水飞蓟宾。提取方法主要包括回流提取、酶辅助提取、索氏提取及气体膨胀液提取等。在纯化操作中,包含重结晶、梯度萃取、柱分离、高速逆流色谱等诸多繁琐步骤。水飞蓟宾可用于治疗皮肤癌、肺癌、膀胱癌等多种癌症。现结合近期的抗癌作用研究,对水飞蓟宾的植物来源及相关提取纯化方法进行系统归纳和总结,以期为水飞蓟宾的研发和应用提供较为全面的参考。 

关键词: 水飞蓟宾, 植物来源, 提取, 纯化, 抗癌活性

Abstract:

Silybin is a flavonoid that can be commonly found in a diversity of plants.The purification and preparation of silybin has been being optimized by the natural product researchers for a long time,usually,the defatted plant materials are used for extracting silybin.The extraction methods include heat reflux extraction,enzyme assisted-extraction,Soxhlet extraction,gas-expanded liquid extraction and so on.The purification operation involves many tedious steps such as recrystallization,gradient extraction,column separation and high speed countercurrent chromatography.Silybin can be used to treat skin cancer,lung cancer,bladder cancer and many other cancers.Here,according to the most recently reported anti-cancer activities,research process on silybin in terms of its plant origin,extraction and purification are systematically summarized in this paper,in order to provide a more comprehensive reference for the development and application of silybin.

Key words: silybin, plant origin, extraction, purification, anti-cancer activity

中图分类号:  R931.6