Novel Secondary Metabolites with Cytotoxic Activities Produced by Verrucosispora sp. FIM06031 from Marine Sponge

NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2011, Vol. 23 ›› Issue (5): 797-800.

Novel Secondary Metabolites with Cytotoxic Activities Produced by Verrucosispora sp. FIM06031 from Marine Sponge

NIE Yi-lei1, WANG Chuan-xi1, ZHENG Yong-biao2, LIN Ru1, XU Li-yan3, Peng Fei1, FANG Dong-sheng1, LIAN Yun-yang1, JIANG Hong1*

1Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian institute of microbiology, Fuzhou 350007, china; 2Life sciences College of Fujian Normal Univesity, Fuzhou 350108, china; 3Shantou University Medical College, Shantou 515041, china

Received:2011-04-20 Online:2011-10-25 Published:2011-09-26

Abstract

Abstract: Three compounds (1-3) were isolated from culture broth of Verrucosispora sp. FIM06031 from marine sponge by silica gel, sephadex LH-20 and C18 reversed phase column chromatography. On the basis of spectral data, they were identified as a novel sesquiterpenoid harrucomicin C (1), cyperusol C (2), and N_b-acetyltryptamine (3). Compound 1 showed prominent growth inhibitory activity against the tumor cell lines HepG2, EC109 and HeLa with IC₅₀ values of 16.99 μM, 25.33 μM and 34.64 μM, respectivity in vitro by MTT assay, while 2 showed growth inhibitory activity against HeLa and HepG2 cells with IC₅₀ values of 149.99 μM and 167.78 μM, respectively.

Key words: Verrucosispora, cytotoxic activity, harrucomicin C, sesquiterpenoid, cyperusol C

CLC Number:

R284.2

NIE Yi-lei, WANG Chuan-xi, ZHENG Yong-biao, LIN Ru, XU Li-yan, Peng Fei, FANG Dong-sheng, LIAN Yun-yang, JIANG Hong*. Novel Secondary Metabolites with Cytotoxic Activities Produced by Verrucosispora sp. FIM06031 from Marine Sponge[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2011, 23(5): 797-800.

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Novel Secondary Metabolites with Cytotoxic Activities Produced by Verrucosispora sp. FIM06031 from Marine Sponge

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