Abstract: The objective of this study was to observe the hypoglycemic effect of ethanol extract from Panax ginseng and Acanthopanax senticosus on diabetic mice induced by streptozotocin (STZ), and to explore its preliminary hypoglycemic mechanism.In this experiment fasting injection of STZ was used to establish the mouse model of diabetes.Randomized control method was used to divide mice into different groups,includes 4 of high-dose groups (400 mg/kg),4 of low-dose groups (200 mg/kg), glibenclamide group,model group and normal control group.Each group was ig administrated with different concentrations of ethanol extract of P.ginseng and 75% ethanol extract of A.senticosus for 6 consecutive weeks.The contents of body weight,fasting blood glucose (FBG), glucose tolerance,serum Insulin levels and antioxidant levels were assayed after the last ig administration.The results showed that compared with those of the normal control group,FBG levels of model group increased significantly (P<0.01),body weigh decreased;compared with those of the model group,FBG levels,glucose tolerance of high-dose groups and low-dose groups were significantly lower than the model group (P<0.01 or P<0.05),insulin sensitivity and antioxidant activity were improved.In conclusion, P.ginseng combined with A.senticosus can effectively improve fasting blood glucose levels of diabetic mice.However,it was found that 50% ethanol extract of P.ginseng with 75% ethanol extract of A.senticosus showed the most significant hypoglycemic effects.The mechanism was possibly through improving antioxidant levels,increasing ISI and improving the insulin sensitivity in hyperglycemic.

Key words: Panax ginseng, Acanthopanax senticosus, hyperglycemias;insulin sensitivity;antioxidant activity