Synthesis of Podophyllotoxin Derivative and Its in Vitro Antitumor Activities

Abstract

Abstract: The aim of this study was to develop a new synthetic method for the synthesis of podophyllotoxin derivative and to investigate the antitumor activity of the synthesized compound.The podophyllotoxin derivative was synthesized using podophyllotoxin as the starting material through a two-step processes including SN₁ nucleophilic displacement followed by condensationhydrolysis.The targeted compound was identified by ¹H-NMR,MS.The antitumor activity of the compound was investigated by MTT assay.The results showed that the cytotoxicity of the new compound was similar to that of etoposide.

Key words: podophyllotoxin, epipodophyllotoxin, synthesis, antitumor activity

CLC Number:

R914.5

XI Wen-li1, SHI Jun-ping1*, ZHANG Ying1, HOU Bao-feng1, KANG Wen-yi2. Synthesis of Podophyllotoxin Derivative and Its in Vitro Antitumor Activities[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(4): 594-596.

[1]	SUN Xiao-fei, SONG Nan, CAO Yuan, YANG Ying, ZHU Jing-xuan, GAO Hao, WANG Jia-xin, JIA Lian-qun. Mechanism of gypenoside in improving non-alcoholic fatty liver disease based on SQLE/CA3/SREBP1c pathway [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(4): 687-693.
[2]	HUANG Yu-ting, MA Yuan, LI Shun-xiang, LI Juan. Research progress on tropoloisoquinoline and azafluoranthene alkaloids [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(12): 2367-2379.
[3]	CHEN Xiao-ming, HE Xi, LYU Jing-kun, XIE Yi, JIANG Hong-yu. A new cyclopeptide from Selaginella pulvinata [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2025, 37(11): 2028-2034.
[4]	HE Wei, LIU Xiao-lu, LUO Wen-fang, ZHOU Jun-hui, HOU Xin-qiang, GUO Rui, XU Jian-jun, SONG Su-qin. Study on the metabolites of the potato scab pathogen strain Streptomyces bobili K6 from Xinjiang [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(增刊2): 37-42.
[5]	CHEN Hui-juan, ZHANG Xing-ping, LI Ming-ming, WANG Kou. Total synthesis of broussonin C with tyrosinase inhibitory activity and its structural simplification [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(7): 1226-1230.
[6]	XIE Guo-xuan, TAMASHA·Kurmanjiang, WANG Hao, CHEN Yun-jie, NURAMINA·Mamat, WANG Xiao-jing, LI Jin-yu. Enzymatic preparation and antitumor activity of Brassica rapa L. isothiocyanate [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(6): 1032-1044.
[7]	ZHANG Wen-ting, YANG Min-jing, MEI Yu, WANG Ji-hua. Research status of kinsenoside [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(2): 348-356.
[8]	ZHANG Tian-tian, ZHENG Bing-song, YUAN Hu-wei, YAN Dao-liang. Research progress on synthetic and metabolic pathways of plant volatile organic compounds and their release and sensing regulatory mechanisms [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2023, 35(6): 1068-1080.
[9]	CAI Chang-chun, FENG Ji, CHENG Ling, RAO Xiong-fei, ZHANG Jian-feng. Research progress and prospects on synthesis of taxol [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(增刊2): 155-162.
[10]	WANG Jun, FU Jian-hong, WANG Yu-miao, RUAN Wen-wei, NIE Hui-lin, CUI Feng-zhen, . Identification of a Streptomyces setonii from Lop Nur and inhibition effects of its metabolites on tyrosinase activity and melanin synthesis [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(9): 1548-1556.
[11]	MUKAIDAISI·Maihemuti, CHEN Jian, JIAO Chun-wei, XIE Yi-zhen. Progress in biosynthesis and application of L-ergothioneine [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(4): 713-721.
[12]	ZHOU Li-qian, HUANG Yao, LU Yan, YE Zi-yu, LIU Xin-lan, DING Xiang, HOU Yi-ling. Structural identificatin and in vitro antitumor activity of wild Morchella esculenta polysaccharide from Xiaojin County of Sichuan Province [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(12): 2077-2088.
[13]	LIU Tian-fu, DU Xiao-nian, ZHANG Yi-fu, ZHANG Jian. Research progress on synthesis and activity of andrographolide derivatives [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(12): 2142-2161.
[14]	XU Xian-li, LIU Ying-ying, SHEN Jian-wei, FENG Hai-sheng, MA Shi-zhen, LI Cai-xia. Study on separation and purification of podophyllotoxin from Sinopodophyllum hexandrum using microporous resin combined with preparative high-performance liquid chromatography [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(增刊2): 73-83.
[15]	CHEN Xiao-min, ZHOU Jun-jie, LI Jia-wei, CHEN Hao-xin, LIU Wen-li, XIE Guo. Research progress on synthesis and transformation of ginsenoside Rg₃ [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(增刊2): 155-164.

Synthesis of Podophyllotoxin Derivative and Its in Vitro Antitumor Activities

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments