Abstract: The hypoglycemic effect of n-butanol extract of Brassica rapa on alloxan diabetic mice was explored.The mice were fasted for help but water after 24h,and the model of diabetic mice was built by peritoneal injection of alloxan solution 160 mg/kg, 60 h and then fasted for another 12 h.When the blood glucose level was greater than 11.1 mmol/L (fasting blood glucose in tail vein),the mice model was defined as a successful experimental model.Ten blanks were reserved as control group,all the model mice were randomly divided into model group,n-butanol extract components low and high dose (20,40 g/kg )group and positive control group (HETTY HERBR DIET βⅡ225 mg/kg),which were perfused one time per day for 14 days.During the experimental period,the blood glucose level was measured by cutting tail before or after building the models,and medication after 7,14 days.After the experiment,mice eyeball blood serum was collected and separated,the activity of SOD and content of MDA were determined.The results showed that compared with the model group,mice blood glucose levels decreased significantly after administering 7,14 d of B.rapa n-butanol extract (P<0.01);SOD activity significantly enhanced (P<0.01);MDA content decreased significantly (P<0.01).These results indicated that B.rapa n-butanol extract can significantly decrease blood glucose level.It showed antioxidant activity in diabetic mice induced by alloxan.

Key words: Brassica rapa, hypoglycemic, alloxan, SOD, MDA