Abstract: In this study, in vivo and in vitro treatments were carried out to investigate the hypoglycemic and antidiabetic effects of Suillus luteus ethanol extract (SLE).SLE exhibited potent inhibitory activity against α-glucosidase in a dose-dependent manner.The EC₅₀ of SLE was 3.269 mg/mL.Streptozotocininduced diabetic mice showed that SLE can decrease the levels of blood glucose,serum total cholesterol (TC),triglyceride (TG),and low density lipoprotein (LDL-C) and increase the level of high density lipoprotein (HDL-C).The weight of the diabetic mice was increased after the SLE treatment.In addition,the pathological changes of pancreas,liver and kidney tissues in the mice model were recovered after the SLE was added.In conclusion,SLE exhibited better antidiabetic activity.It can be used for the development of health food or medicine.

Key words: Suillus luteus, ethanol extract, streptozotocin-induced diabetic mice, hypoglycemic, antidiabetic