Abstract: Propolis is a resinous substance which is collected by bees from tree exudates primarily resins and mixed with secretions of mandibular gland and wax gland.It has a complex chemical composition and extensive biological activities.In this article,the researches about the anti-tumor activity of propolis from different geographic regions and their isolations were summarized.Meanwhile,the anti-tumor mechanisms of propolis as inducing apoptosis,inhibiting cell proliferation and signal transduction pathway,anti-angiogenesis,anti-tumor metastasis and cancer prevention were also involved.By summarizing these researches,we aimed to provide insights for the further studies in these areas and for translating propolis to an effective anti-tumor drug.

Key words: propolis, anti-tumor activity, mechanisms, review