NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (5): 651-654.

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Chemical Constituents from Ganoderma applanatum and Absolute Configuration Determination of New Compounds

BU Qing-hua1,2#,LUO Qi2#,CHENG Yong-xian2*   

  1. 1 College of Pharmaceutical Science,Dali University,Dali 671002,China; 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China
  • Online:2016-05-28 Published:2016-09-06

Abstract: Eight compounds including two new compounds,namely shushenes A (1) and B (2),were isolated from the fruiting bodies of Ganoderma applanatum. Their structures were identified by means of spectroscopic methods.The structures of the known compounds are lucidulactone A (3),2,3-dihydroxy-1-(4-hydroxy3,5-dimethoxyphenyl)-1-propanone (4),6-hydroxy-4-H-chromen-4-one (5),1-(4-ethylphenyl)-1,2-ethanediol (6),1-(2-ethylphenyl)-1,2-ethanediol (7) and indole-3-carboxaldehyde (8),which were all isolated from this species for the first time.Of note,compounds 1 and 2 were isolated as racemic mixtures,chiral separation followed by computational methods allowed their absolute configuration assignment.In addition,inhibition of compounds 1 and 2 on fibronectin expression was tested by using an enzyme-linked immunosorbent assay (ELISA).