Abstract: The aim of this study was to explore the anti-acute gastric ulcer effects of Portolaca oleracea L.induced by ethanol.SD Rats were randomly divided into normal group,model group,ranitidine group and low,medium and high dose Portolaca oleracea L.groups(8 in each group).The ulcer index of gastric mucosa,the contents of malondialdehyde(MDA),nitric oxide(NO) and epidermal growth factor(EGF),the activity of superoxide dismutase(SOD) in serum and gastric mucosa tissues,total gastric acidity value and gastric protease activity were measured after 14 day’s intragastric administration.The results showed that gastric ulcer index and the content of MDA in serum were significantly decreased in high and medium dosage groups of P.oleracea, but the contents of NO in serum,EGF in gastric mucosa and SOD activity in gastric mucosa were significantly increased.In high dosage group of P.oleracea, the SOD activity in serum was significantly increased,while the content of MDA in gastric mucosa tissues,the total gastric acidity value and gastric protease activity were significantly decreased.In conclusion, P.oleracea had a significant anti-acute gastric ulcer effects induced by ethanol.

Key words: Portolaca oleracea L., gastric ulcer, malondialdehyde, superoxide dismutase, nitric oxide, epidermal growth factor