Abstract: Due to the unique living environment,marine-derived actinomycetes have novel metabolic pathways.In recent years,many alkaloids with remarkable activity and novel structure have been found from marine-derived actinomycetes,some of which have entered into the pre-clinical research.These active alkaloids provide tremendous lead compounds for drug discovery and development.In order to lay the foundation for the research of marine derived actinomycetes alkaloids,the chemical structure,source and biological activity of the new alkaloids from marine-derived actinomycetes since 2010 were introduced.

Key words: marine, actinomycetes, alkaloids, review