NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2017, Vol. 29 ›› Issue (1): 27-33. doi: 10.16333/j.1001-6880.2017.1.005

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Ginkgo biloba Extract Release Agent Acupoint Embedding Therapy Attenuates the Injury of Cerebral Ischemia/Reperfusion through Nrf2/HO-1 Signal Pathway

YANG Jing1*,WU Feng-zhi2,LI Yu-xia3,ZHANG Dong-sen3   

  1. 1 Department of traditional Chinese medicine,The workers’ hospital of Tangshan,Tangshan 063003,China; 2 Beijing university of Chinese medicine,Beijing 100029,China; 3 Department of neurology,The workers’ hospital of Tangshan,Tangshan 063003,China
  • Online:2017-01-31 Published:2017-02-17

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Abstract: The aim of this study was to observe the effects of Ginkgo biloba extract release agent acupoint embedding (GBER) therapy on brain injury and Nrf2/HO-1 signal pathway after cerebral ischemia/reperfusion in rats.Cerebral ischemia/reperfusion rat model was induced by the modified middle cerebral artery occlusion model (MCAO) method.The neurological deficit score and histopathological examination of hippocampal CA1 were performed.The levels of malondialdehyde (MDA),nitric oxide (NO),superoxide superoxide dismutase (SOD) and glutathione (GSH) were assayed.Nrf2/HO-1 mRNA and protein expressions of brain tissue were detected.The results showed that G.biloba extract sustained-release agent significantly increased the neurological deficit score,the number of neurons.GBER not only reduced the content of MDA and NO,but also augmented the activity of SOD and the content of GSH.The mRNA and protein of Nrf2/HO-1 in GBER group enhanced.These findings showed that GBER therapy attenuated the injury of cerebral ischemia/reperfusion via regulating Nrf2/HO-1 signal pathway.

Key words: cerebral ischemia, reperfusion injury, Ginkgo biloba extract, acupoint embedding, Nrf2, HO-1

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