Abstract: Sixteen lanostane triterpenoids were isolated from the ethanol extract of Ganodermasessile by means of preparative HPLC,column chromatography over sephadex LH-20,silica gel,ODS and were identified as ganoderic acid LM-2 (1),ganosporeric acid A (2),ganoderic acid J (3),ganoderic acid C (4),ganoderic acid A (5),ganoderic acid B (6),ganoderic acid M (7),ganoderic acid C-6 (8),ganoderic acid AM-1(9),ganoderic acid G(10),ganoderic acid I(11),ganolucidic acid A (12),ganoderic acid ε(13),ganoderic acid H(14),ganolucidic acid E (15),ganoderic acid D (16).Compounds 1-16 were isolated from this Species for the first time.Compounds 2,5,6,11,15 and 16 exhibited hepatoprotective activities.The survival rate were 60%,45%,56%,44%,47% and 47% in HL-7702 cells respectively,all higher than 42% of bicyclol.

Key words: Ganoderma, Ganoderma sessile, triterpenoids, hepatoprotective activity