Abstract: Houttuynlae cordata was a traditional medicine resource with a wide range of biological activities and edible value,which had great potential for development.Alkaloids,as the effective ingredients of H.cordata, are diverse in chemical structures and have extensive bioactivities so that it has become the focus of researchers.Herein,the progress of research on the chemical constituents and bioactivities of alkaloids which were extracted and separated from H.cordata were reviewed in this paper.To date,71 compounds of alkaloids isolated from H.cordata had been reported in literatures,including aporphine,aristolone lactam,amide,pyridine and other types,etc.Research results from pharmacological experiments shown that these compounds displayed anti-tumor,anti-virus,anti-platelet aggregation,anti-inflammatory,hypoglycemic and other biological activities.In conclusions,based on the study of the chemical constituents and bioactivity of alkaloids in H.cordata,the present paper may provide to a reference for clarification of pharmacologically active ingredients,quality evaluation,and further explorations.

Key words: Houttuynlae cordata, alkaloids, chemical constituents, biological activities