Abstract: The aim of this study was to compare the ingredient and hepatoprotective activity of different extracts of Swertia chirayita.The method of HPLC and infrared spectroscopy was used to compare the ingredient of S.chirayita extracts.Liver injury model induced by CCl₄ in mice was used to compare the hepatoprotective function of water extract and 75% ethanol extract.The results indicated that the intensity of 1280 cm^-1 of swertiamarin,1496 and 1464 cm^-1 of mangiferin,had positive correlation with the content change in different extracts.There had obvious difference between IR spectra of different extracts and between intensity of targeted ingredient of different extracts.The pharmacology experiments results proved the water extracts and 75% ethanol extracts had clear hepatoprotective function,and during the dose range of 0.5-2.0 g/kg,the hepatoprotective activity of 75% ethanol extracts showed obvious dose-effect relationship.

Key words: Swertia chirayita, extracts, fourier transform infrared spectroscopy, hepatoprotective activity