In this study,LPS thermogenic model was used to observe the effects of decoction of wild Tetrasfigmae Radix(DWTR) on anal temperature,number and percentage of plasma leukocytes,neutrophils,lymphocytes and monocytes,as well as serum IL-6,PCT,CRP and IL-10 levels in febrile immature rats.The results showed that compared with the normal control group,the body temperature of immature rats increased significantly after 20 μg/kg LPS stimulation for 2.5 hours (P<0.01).Compared with LPS model group,5 and 10 g/kg DWTR could significantly reduce the body temperature of febrile immature rats (P<0.01).It can significantly reduce the number of white blood cells (P<0.01),the number and percentage of neutrophils (P<0.01),the number of monocytes (P<0.01) and its percentage (P<0.05,P<0.01),and significantly increase the number of lymphocytes (P<0.05) and its percentage (P<0.01).Serum IL-6 content (P<0.05,P<0.01),CRP level (P<0.05,P<0.01) and PCT content (P<0.05) were significantly reduced in immature rats;10 g/kg can improve the level of IL-10 in immature rats (P<0.05).It shows that DWTR has good antipyretic and anti-inflammatory effects on immature rats.