Resveratrol,a non-flavonoid polyphenol compound is widely present in Medicine and food homologous plants.Its anti-tumor effects have been widely recognized,but there is no experimental data reflecting the inhibition of cervical cancer in vivo.We found that resveratrol significantly inhibited tumor growth with upregulation of expression level of LC3B and Beclin-1,while the expression level of P62 was downregulated.Thus,this suggests that resveratrol may inhibit the progress of cervical cancer by promoting excessive autophagy.Furthermore,resveratrol induced autophagy-related VMP1,Beclin-1,and LC3B protein expression and promoted the formation of autophagosomes and autophagolysosomes in vitro.Finally,it was found that resveratrol promoted excessive autophagy when combined with the activator rapamycin.It also promoted cell apoptosis when combined with the autophagy inhibitor bafilomycin A1.In conclusion,resveratrol exhibits inhibitory effects on cervical cancer during both autophagy activation and inhibition.