HPLC method was used to determine the fingerprint of Erigerontis Herba standard decoction.Its antioxidant activity in vitro was determined.The quality of Erigerontis Herba decoction was evaluated by bivariate correlation analysis and stoichiometry.The scavenging rate of 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) free radical and 2,2′-hydrazine - (3-ethylbenzothiazoline-6-sulfonic acid) diammonia salt (ABTS) free radical were used as pharmacodynamic indexes to determine the antioxidant capacity.The content of total flavonoids was determined by UV-visible spectrophotometry.The fingerprint of Erigerontis Herba standard decoction was established by HPLC.Bivariate correlation analysis was used to screen out the analysis variables that were significantly correlated with DPPH and ABTS radical 50% inhibition rate (IC₅₀).Further,cluster analysis (CA) and principal component analysis (PCA) were used to evaluate the quality of Erigerontis Herba standard decoction.The IC₅₀ values of Erigerontis Herba standard decoction DPPH were 1.00~3.39 mg/mL and 0.254~2.16 mg/mL for ABTS.The total flavonoid content was 2.85~11.3 mg/mL,and the IC₅₀ value was significantly correlated with the total flavonoid content (r=-0.718,r=-0.841).The similarity of fingerprints was 0.770~0.993,21 common peaks were obtained,and 8 known components were identified with reference substance. A total of 10 and 13 common peaks were found to be significantly correlated with IC₅₀ of DPPH and ABTS by bivariate correlation analysis.Cluster analysis and principal component analysis divided the samples into two categories and established the principal component scoring model.F_DPPH=0.719 9F₁+0.112 3F₂+0.099 27F₃,F_ABTS=0.700 5F1+0.131 9F₂+0.086 57F₃.Based on CA and PCA,OPLS-DA was further used to find that peaks 11,13,14 and 15 were the main difference peaks related to DPPH free radical scavenging.Peaks 11,15,14 and 8 were the main difference peaks associated with ABTS free radical scavenging.This paper evaluated the quality of Erigerontis Herba standard decoction by combining spectrum and efficiency,which could provide basis for the quality control of Erigerontis Herba and its preparations.