Ganoderma lucidum is an important dual-use fungus with a long history both at medicinal and edible.At present,about 100 species of G. lucidum are known.Polysaccharide is one of the main active ingredient of G. lucidum.It can inhibit the proliferation and differentiation of tumor cells,regulate congenital immune cells,microbial groups and the expression of inflammatory factors in the body,and terminate reactions of free radical chain.It can also increase the vitality of cells and antioxidant enzymes,regulate the metabolism of lipids and organic compounds in the liver,inhibit the apoptosis of myocardial cells,inhibit the activation of microglia and astrocyte,etc.Thus,it has pharmacological effects such as anti-tumor,immunomodulatory,anti-inflammatory, hypoglycemic,hypolipidemic, anti-fatigue,anti-oxidation,protection myocardial and liver,regulating central nervous system and so on.In this paper,the pharmacological effects and mechanisms of G. lucidum polysaccharides in recent three years are reviewed,with a view to provide reference for further development and utilization of G. lucidum polysaccharides.