In order to evaluate the medicinal and edible value of different cultivated varieties of citrus peel,the total flavonoids were determined by ultraviolet and visible spectrophotometry (UV) and the contents of narirutin,hesperidin,sinensetin,naringin,and tangeretin were determined by high performance liquid chromatography (HPLC).The antioxidant activity was compared by free radical scavenging test,and further compared with the comprehensive quality evaluation method of multivariate statistical analysis.The results showed that the total flavonoid content of C. reticulata ‘Dahongpao’ (DHP) was significantly higher than that of C. reticulata ‘Ai Yuan 38’ (AY38),C. reticulata ‘Chun Jian’ (CJ),C. reticulata  ‘Wo Gan’ (WG) and C. reticulata ‘Gan Ping’ (GP) (P < 0.05),and there was no difference in the content and antioxidant capacity of  C. reticulata ‘Unshiu’ (CLU),C. reticulata Blanco cv.Ponkan (PK),C. reticulata ‘Qing Jian’ (QJ) and C. reticulata ‘Mingri Jian’ (MRJ),indicating that the latter four citrus peel extracts could be used as natural antioxidants.The content of CLU and QJ hesperidin was significantly higher than that of DHP,which could be used as raw materials for hesperidin extraction.The contents of total flavonoids,five flavonoid monomers and antioxidant activity of PK were close to those of DHP.The results of cluster heat map and technique for order preference by similarity to an ideal solution(TOPSIS) analysis showed that DHP and PK were clustered into one group,and the top two comprehensive scores were ranked.It can be inferred that PK has the potential as a medicinal cultivar.The results of this study will provide a reference for the evaluation of the medicinal and edible value of citrus peel.