Three active components such as chlorogenic acid and total ash content were determined after different drying methods of Chrysanthemi Flos,and this was used as the basis for screening Chrysanthemi Flos treatment methods,in order to get the best processing method of Chrysanthemi Flos.Firstly,the same batch of fresh Chrysanthemi Flos were processed using five drying methods:sun drying,drying,traditional shade drying,steaming followed by drying,and steaming followed by sun drying.Then,high-performance liquid chromatography (HPLC) was used to analyze the content of chlorogenic acid,luteoloside,and 3,5-O-dicaffeoyl quinic acid in the Chrysanthemi Flos samples obtained from the five different drying methods,and the total ash content of Chrysanthemi Flos was determined according to the relevant provisions of the Chinese Pharmacopoeia.The results showed that under five different drying methods,the total ash content of Chrysanthemi Flos ranged from 5.26% to 6.85%.The content of chlorogenic acid is 2 385.15-3 783.96 μg/g.The content of luteoloside is 84.74-618.92 μg/g.The content of 3,5-O-dicaffeoyl quinic acid is 3 359.78-5 438.49 μg/g.The total content of Chrysanthemi Flos obtained by drying method is the highest,followed by shade drying method,steaming and drying method,sun drying method,and steaming and drying method;The total ash content of Chrysanthemi Flos obtained by sun drying method is the highest,followed by shade drying method,steaming followed by sun drying method,drying method,and steaming followed by drying method.