NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (5): 724-727. doi: 10.16333/j.1001-6880.2016.5.015

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Preparation,Characterization and in vitro Release Behavior of 10-Methoxycamptothecin loaded Sustained Release Nanoparticles

LI Si-yang1,KONG Qing-xin1,ZHANG Rui1,WANG Yang2*   

  1. 1 Jiangsu Food & Pharmaceutical Science College,Huaian 223003,China; 2 Alkali Soil Natural Environmental Science Center,Northeast Forestry University,Key Laboratory of Saline alkali Vegetation Ecology Restoration in Oil Field,Ministry of Education,Harbin 150040,China
  • Online:2016-05-28 Published:2016-09-06

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Abstract: The polylactic acid(PLA) was used as the material with 10-methoxycamptothecin(MeOCPT) as model drugs,the sustained-release nanoparticles for MeOCPT was successfully prepared and characterized by emulsion solvent evaporation method.The sustained-release nanoparticles was obvious spherical structure by transmission electron microscopy(TEM) observations.The optimal ratio of MeOCPT to PLA was 0.02:1.The particle size distribution was 100250 nm.The satisfactory encapsulation efficiency and drug-loading content were up to 83.57±3.45 and 3.10±1.19%,respectively.The in vitro release studies showed that 70% of MeOCPT was released from the sustained-release nanoparticles in the first 48 h which had obvious slow release effect.In conclusion,the sustained-release nanoparticles for MeOCPT were successfully prepared by emulsion solvent evaporation method which providing basis for further research of PLA as drug controlled release carrier and direction for the research of small molecular drugs.

Key words: 10-methoxycamptothecin, nanoparticles, preparation, haracterization, in vitro release

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