Abstract: In recent years,researches on molecular biology and pharmacology of aging have been rapidly progressed.Looking for anti-aging compounds is becoming a focus and hot spot in aging field.On one hand,a variety of natural products,especially Traditional Chinese Medicines (TCM),are of great benefit to disease prevention and human health,their roles in anti-aging are getting an increasing attention.On the other hand,the importance of mitochondria in regulation of aging is widely recognized and confirmed.Here,a number of anti-aging natural products (either pure compounds or extracts) targeting at mitochondria function were reviewed,which would provide a theoretical basis and direction for the further research and development of natural products.

Key words: anti-aging, natural products, mitochondria, molecular mechanisms, signaling pathways