Endometrial cancer (EC) is one of the three most common malignant tumors of the female reproductive tract,and its morbidity and mortality are increasing year by year.As a multi-pathway,multi-target,highly effective and low toxicity adjuvant drug against cancer,traditional Chinese medicine and natural products have been widely used in recent years in domestic and international research.This article summarizes the mechanism of action of Chinese herbal medicine and natural products in EC,including regulation of multiple signaling pathways,inhibition of cell proliferation,blocking tumor proliferation and metastasis,induction of apoptosis and regulation of cell autophagy,etc.,in order to provide theoretical references for the development and utilization of anti-EC drugs.