This study aims to explore the potential mechanism of Maxing Shigan Decoction (MXSGD) for treating different diseases with same method on influenza and COVID-19 based on network pharmacology.First,the main active ingredients and targets of MXSGD were collected in the TCMSP and Batman-TCM database.Second,the GeneCards database,NCBI gene database and OMIM database were searched to obtain disease targets of influenza and corona virus disease 2019 (COVID-19).Third,after obtaining the common target,the STRING database was used to construct a protein interaction network,and the GO and KEGG function enrichment analysis was performed through the DAVID database.We finally screened and obtained 136 active ingredients and 158 targets of MXSGD,2 634 targets for influenza,3 340 targets for COVID-19 and 59 intersection targets.The results of GO functional enrichment analysis showed that MXSGD involved 1 789 biological processes,60 molecular functions,and 23 cell components.KEGG pathway enrichment analysis has obtained 154 signal pathways,mainly including IL-17 signaling pathway,Th17 cell differentiation,C-type lectin receptor signaling pathway,TNF signaling pathway,Toll-like receptor signaling pathway and HIF-1 signaling pathway.In conclusion,the mechanism of MXSGD for treating different diseases with same method on influenza and COVID-19 has the characteristics of multi-component,multi-target,multi-channel interaction.Multi-components play multiple effects (anti-inflammatory,anti-oxidative stress,etc.) by regulating a series of signal pathways closely related to the pathophysiology of influenza and COVID-19.

"> Maxing Shigan Decoction, influenza, corona virus disease 2019, treating different diseases with the same treatment, mechanism, network pharmacology