Vasorelaxant Effect on Isolated Rabbit Aortic Rings and Chemical Constituents of n-Butanol Fraction from Leaves of Magnolia officinalis Rehd et Wils.

doi:A

Abstract

Abstract: Isometric tension measurements were used to study the vasorelaxant effect of n-butanol fraction of the leaves of Magnolia officinalis on isolated rabbit aortic rings with and without endothelium induced by norepinephrine. The results showed that the n-butanol fraction caused vasorelaxation on rabbit aortic rings with and without endothelium preconstracted with norepinephrine in a dose-dependent manner, which may be related to the quercitrin and rutin. Seven compounds were obtained and identified as quercitrin (1), rutin (2), syringing (3), syringaresinol-4,4′-di-O-β-D-glucoside (4), sinapaldehyde 4-O-β-D-glucopyranoside (5), pinoresionol -4-O-β-D-glucopyranoside (6), and syringaresinol-4-O-β-D-glucopyranoside (7). Compounds 4 and 6 were isolated from this plant for the first time.

Key words: leaves of Magnolia officinalis, vasorelaxation, chemical constituents, quercitrin, rutin

CLC Number:

R932

YANG Zhu-ya, WEI Ying-fang, ZHOU Zhi-hong, LONG Fei. Vasorelaxant Effect on Isolated Rabbit Aortic Rings and Chemical Constituents of n-Butanol Fraction from Leaves of Magnolia officinalis Rehd et Wils.[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(3): 298-302.

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