Preparation of Tanshinone ⅡA Derivatives and Their Proliferation Inhibitory Activity against HeLa Cells

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Abstract

Abstract: Five derivatives of Tanshinone ⅡA were prepared via Mannich reaction with esterified amino acid. Their structures were characterized by spectral data. The antiproliferative activities of Tanshinone ⅡA and the derivatives against HeLa cells were evaluated by MTT assay. All the five derivatives showed higher activity than Tanshinone ⅡA, which suggested that modification at C-16 of Tanshinone ⅡA could enhance its inhibitory activity on tumor cells.

Key words: Tanshinone ⅡA, structure modification, Mannich reaction, HeLa cell, cytotoxicity

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JIANG Cheng-feng, LI Rui-feng, XU Dan, YANG Fu-jun, SHEN Xiu, XU Wen-qing. Preparation of Tanshinone ⅡA Derivatives and Their Proliferation Inhibitory Activity against HeLa Cells[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2012, 23(3): 385-388.

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Preparation of Tanshinone ⅡA Derivatives and Their Proliferation Inhibitory Activity against HeLa Cells

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