天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (2): 367-371.doi: 10.16333/j.1001-6880.2015.02.033

• 综述 • 上一篇    

川芎嗪抗组织粘连研究进展

颜帅,李文林,曾莉*   

  1. 南京中医药大学,南京 210023
  • 出版日期:2015-02-15 发布日期:2015-02-15

Review on Anti-adhesion Activity of Tetramethylpyrazine

YAN Shuai,LI Wen-lin, ZENG Li*   

  1. Nanjing University of Chinese Medicine,Jiangsu Nanjing 210023,China
  • Online:2015-02-15 Published:2015-02-15

摘要: 对近年来川芎嗪抗组织粘连的作用,为临床研究和研发新药提供参考。结果发现,川芎嗪可通过抑制胶原增生过度、与粘连相关的因子过度表达、降低血浆中白细胞和纤维蛋白的浓度等多靶点、多环节发挥抗粘连作用。但是研究多集中在体外实验及动物实验,亟需进一步从临床研究上证实其抗粘连作用,未来基础研究应集中在川芎嗪生物材料的研发。

关键词: 川芎嗪, 粘连, 药理作用

Abstract: Recent studies of anti-adhesion mechanism of tetramethylpyrazine were reviewed to provide reference for clinical study and new drug development.It was found that the anti-adhesion mechanism of tetramethylpyrazine involved multi-targets and multi-links such as the inhibition of proliferation of collagen,over-expression of adhesion related factors,and reduction of the concentration of white blood cells and fibrin in plasma.In future,more clinical evidence was still required,and the basic research of tetramethylpyrazine should be focused on the biomaterial development.

Key words: tetramethylpyrazine, adhesion, pharmacological activity

中图分类号: 

R264