天然产物研究与开发 ›› 2015, Vol. 27 ›› Issue (Suppl): 192-196.doi: 10.16333/j.1001-6880.2015.S.044

• 综述 • 上一篇    下一篇

姜黄素抗前列腺癌的药理学研究进展

石群,马淑梅,陈秀华*   

  1. 中国医药工业研究总院上海医药工业研究院创新药物和制药工艺国家重点实验室,上海 2000437
  • 出版日期:2015-12-01 发布日期:2016-01-12

Review on Pharmacological Activity of Curcumin on Prostate Cancer

SHI Qun,MA Shu-mei,CHEN Xiu-hua*   

  1. State Key Lab of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437 China)
  • Online:2015-12-01 Published:2016-01-12

摘要: 前列腺癌是欧美国家发病率最高的恶性肿瘤之一,寻求新颖、有效的预防措施具有十分重要的意义。姜黄素是从姜科植物中提取的酸性酚类物质,近年来发现其具有抗炎、抗氧化、抗肿瘤等多方面的药理作用。凭借其多元化的药理学作用及毒副作用小的特点,众多科研工作者对其作用于前列腺癌进行了大量研究。本文将对姜黄素预防及治疗前列腺癌的机制、药动学、临床研究进展进行总结。

关键词: 天然产物, 姜黄素, 前列腺癌

Abstract: Prostate cancer is one of the most prevalent malignancies in men in Western countries.The burden of increasing morbidity and mortality due to prostate cancer imposes a need for new,effective measures of prevention in daily life.Curcumin,derived from the root of Curcuma longa, possess anti-inflammatory, antioxidant, anti-angiogenic properties. Extensive research indicated that this natural product can both prevent and treat prostate cancer.This article summarized the mechanism,pharmacokinetic and clinical research progress of curcumin’s prevention and treatment of prostate cancer.

Key words: natural product, curcumin, prostate cancer

中图分类号: 

R966