天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (4): 715-721.doi: 10.16333/j.1001-6880.2017.4.029

• 综述 • 上一篇    

天然植物抗假丝酵母菌活性成分的研究

赵诗景1,应泽茜1,何小稳1,2*   

  1. 1海南医学院,海口 571199;2河北医科大学,石家庄 050017
  • 出版日期:2017-04-29 发布日期:2017-05-08

Research Progress of Active Constituents from Natural Plants Against Candida spp.

ZHAO Shi-jing1,YING Ze-xi1,HE Xiao-wen1,2*   

  1. 1 Hainan Medical University,Haikou 571199,China;2Hebei Medical University,Shijiazhuang 050017,China
  • Online:2017-04-29 Published:2017-05-08

摘要: 临床真菌感染的发病率和死亡率逐年上升,其中以假丝酵母菌为代表的侵袭性真菌感染尤为严重,目前主要抗真菌药物的耐药性日趋严重,且多数具有毒副作用,寻找安全有效的新型抗真菌药物迫在眉睫。天然植物中抗真菌活性成分来源广泛,具有低毒、广谱、作用途径多样化等优点,成为新型抗真菌药物的一个重要研究方向。本文主要综述了近年来从天然植物中筛选抗假丝酵母菌活性成分的研究。

关键词: 天然植物, 抗真菌, 假丝酵母菌, 活性成分

Abstract: The incidence of clinical fungal infections has increased dramatically,causing high morbidity and mortality.Currently,with extensive application of broadspectrum antifungal agents,there has been a notable increase in drug resistance.In addition,lots of antifungal agents used have different degrees of side effects.Therefore,the development of new and effective antifungal agents is of paramount importance.Recently,studies on active constituents from natural plants have received more and more attention,due to its properties of abundance,low toxicity,broad spectrum and diverse ways of action.In this study,the study on screening active constituents from natural plants in recent years is reviewed.

Key words: natural plants, antifungal, Candida, active constituents

中图分类号: 

R282.71 R978.5