C-21甾体告达亭的羟丙基-β-环糊精包合物对大鼠大脑局灶性缺血的神经保护研究

doi:10.16333/j.1001-6880.2017.S.037

天然产物研究与开发 ›› 2017, Vol. 29 ›› Issue (增刊1): 186-189.doi: 10.16333/j.1001-6880.2017.S.037

C-21甾体告达亭的羟丙基-β-环糊精包合物对大鼠大脑局灶性缺血的神经保护研究

谢凯强1,2，黄烈军2，张蕾3，苑春茂2，顾玮2，冯林音3*，郝小江1,2*

1 贵州大学药学院，贵阳 550025；2贵州省中国科学院天然产物化学重点实验室，贵阳 550002；3中国科学院上海药物研究所，上海201203

出版日期:2017-08-02 发布日期:2017-08-02

Neuroprotective Effect on Focal Cerebral Ischemia in Rats Treatment with the Inclusion Complex of C-21 Steroid Caudatin and Hydroxypropyl-β-Cyclodextrin

XIE Kai-qiang1,2,HUANG Lie-jun2,ZHANG Lei3,YUAN Chun-mao2,GU Wei2,FENG Lin-yin3*,HAO Xiao-jiang1,2*

1 College of pharmacy,Guizhou University,Guiyang 550025,China;2The key laboratory  of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,Guiyang 550007,China;3Shanghai Institute of MateriaMedica,Chinese Academy of Sciences,Shanghai 201203,China

Online:2017-08-02 Published:2017-08-02

摘要/Abstract

摘要： 萝摩科植物富含C-21孕甾烷型的甾体及其皂苷，该类成分对大鼠大脑局灶性缺血的神经保护作用鲜见报道。本文对隔山牛皮消中分离的该类成分告达亭苷元的抗脑缺血保护作用进行了研究，观察告达亭苷元的羟丙基-β-环糊精包合物对大鼠大脑局灶性缺血引起脑损伤的影响，研究结果表明告达亭苷元的羟丙基-β-环糊精包合物具有抗脑缺血作用，并呈剂量依赖性。

关键词: 告达亭, 大鼠大脑局灶性缺血, 神经保护作用

Abstract: There has been few report regarding on neuroprotective effect of C21pregnane steroids and saponins on focal cerebral ischemia in rats.This study investigated the neuroprotective effect of the inclusion complex of caudatin and hydroxypropylβcyclodextrin on focal cerebral ischemia in brain injury rats,and the results indicated caudatin has moderately neuroprotective effect in a dose dependent manner.

Key words: Caudatin, focal cerebral ischemia in rats, neuroprotective effect

谢凯强1,2，黄烈军2，张蕾3，苑春茂2，顾玮2，冯林音3*，郝小江1,2*. C-21甾体告达亭的羟丙基-β-环糊精包合物对大鼠大脑局灶性缺血的神经保护研究[J]. 天然产物研究与开发, 2017, 29(增刊1): 186-189.

XIE Kai-qiang1,2,HUANG Lie-jun2,ZHANG Lei3,YUAN Chun-mao2,GU Wei2,FENG Lin-yin3*,HAO Xiao-jiang1,2*. Neuroprotective Effect on Focal Cerebral Ischemia in Rats Treatment with the Inclusion Complex of C-21 Steroid Caudatin and Hydroxypropyl-β-Cyclodextrin[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2017, 29(增刊1): 186-189.

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C-21甾体告达亭的羟丙基-β-环糊精包合物对大鼠大脑局灶性缺血的神经保护研究

Neuroprotective Effect on Focal Cerebral Ischemia in Rats Treatment with the Inclusion Complex of C-21 Steroid Caudatin and Hydroxypropyl-β-Cyclodextrin

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