天然产物研究与开发 ›› 2018, Vol. 30 ›› Issue (6): 964-967.doi: 10.16333/j.1001-6880.2018.6.008

• 研究简报 • 上一篇    下一篇

山楂中一个具有抗菌活性的黄酮类新化合物

李晶1,孔维松1,刘欣1,耿永勤1,胡秋芬1,李涛2*,杨叶昆1*   

  1. 1云南中烟工业有限责任公司技术中心,昆明 650106;2曲靖市第一人民医院口腔医院,曲靖 655000
  • 出版日期:2018-07-05 发布日期:2018-07-05
  • 基金资助:

    中国烟草总公司科技重点项目(110201502006);云南中烟科技项目(2016JC03);国家自然科学基金(21462051)

A New Flavone from Crataegus pinnatifida and Its Antibacterial Activity

LI Jing1,KONG Wei-song1,LIU Xin1,GENG Yong-qin1,HU Qiu-fen1,LI Tao2*,YANG Ye-kun1*   

  1. 1China tobacco Yunnan industrial Co.,Ltd,Kunming,650106,China; 2Stomatological hospital of Qujing first people′s hospital,Qujing 655000,China
  • Online:2018-07-05 Published:2018-07-05

摘要: 为研究蔷薇科山楂属植物山楂果实的化学成分,本研究采用色谱技术从山楂70%乙醇提取物中分离得到了1个新化合物,波谱学方法鉴定了该化合物结构,命名为:2′-羟基-7-(3-羟丙基)-6-甲氧基-黄酮。生物活性测试表明,该新化合物对耐甲氧西林金黄色葡萄球菌(MRSA)菌株的MIC90值为34.8 ± 3 μg/mL,具有一定的抗菌活性。

关键词: 山楂, 黄酮, 抗菌活性

Abstract: For the research of the chemical components of the fruit of Crataegus pinnatifida, a new compound has been isolated from the ethanol extracts (extracted by 75% ethanol) of this sample by using various chromatographic techniques. Its structure was identified by spectral methods, and was named as 2′-hydroxy-7-(3-hydroxypropyl)-6-methoxy-flavone. The biological activity test showed that this compound exhibited certain antibacterial activity with MIC90 value of 34.8 ± 3 μg/mL for methicillin resistant Staphylococcus aureus (MRSA) strain.

Key words: Crataegus pinnatifida, flavone, antibacterial activity

中图分类号: 

R284.2 Q946