天然产物研究与开发 ›› 2021, Vol. 33 ›› Issue (12): 2146-2156.doi: 10.16333/j.1001-6880.2021.12.019

• 综述 • 上一篇    下一篇

中药及天然产物抗子宫内膜癌作用及机制的研究进展

李璐1,2,3,4，周欣1,2,3,4，龚小见1,2,3,4，赵超1,2,3,4*   

  1. 1贵州师范大学 贵州省山地环境信息系统与生态环境保护重点实验室；2贵州师范大学 喀斯特山地生态环境保护与资源利用协同创新中心；3贵州师范大学 贵州省药物质量控制及评价技术工程实验室；4贵州师范大学 天然药物质量控制研究中心，贵阳 550001
  • 出版日期:2021-12-28 发布日期:2021-12-30
  • 基金资助:
    贵州省高层次创新人才培养项目（黔科合人才（2015）4033）

Progress of research on the antiendometrial cancer effects and mechanisms of traditional Chinese medicine and natural product

LI Lu1,2,3,4,ZHOU Xin1,2,3,4,GONG Xiao-jian1,2,3,4,ZHAO Chao1,2,3,4*   

  1. 1Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment,Guizhou Normal University;2Collaborative Innovation Center for Karst Mountain Ecological Environmental Protection and Resource Utilization (Project of Education Department of Guizhou Province),Guizhou Normal University;3Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine,Guizhou Normal University;4Research Center for Quality Control of Natural Medicine,Guizhou Normal University,Guiyang 550001,China

  • Online:2021-12-28 Published:2021-12-30

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摘要： 子宫内膜癌（endometrial cancer，EC）是常见的女性生殖道三大恶性肿瘤之一，其发病率和死亡率都呈逐年上升趋势。中药及天然产物作为一种多途径、多靶点、高效、毒副作用小的抗癌辅助药物，近几年被广泛应用于国内外的研究中。本文归纳总结了中药和天然产物干预EC的作用机制，包括调控多种信号通路，发挥抑制细胞增殖、阻断肿瘤扩散和转移、诱导细胞凋亡和调节细胞自噬等作用，以期为抗EC药物的研发与利用提供理论参考。

关键词: 中药, 天然产物, 子宫内膜癌, 作用机制

Abstract:

Endometrial cancer (EC) is one of the three most common malignant tumors of the female reproductive tract,and its morbidity and mortality are increasing year by year.As a multi-pathway,multi-target,highly effective and low toxicity adjuvant drug against cancer,traditional Chinese medicine and natural products have been widely used in recent years in domestic and international research.This article summarizes the mechanism of action of Chinese herbal medicine and natural products in EC,including regulation of multiple signaling pathways,inhibition of cell proliferation,blocking tumor proliferation and metastasis,induction of apoptosis and regulation of cell autophagy,etc.,in order to provide theoretical references for the development and utilization of anti-EC drugs.

Key words: traditional Chinese medicine, natural product, endometrial cancer, mechanism of action

中图分类号:  R737.33

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