This paper takes autoimmune disease such as systemic lupus erythematosus and glomerulonephritis as an example,for the purpose of analyzing the mechanism of Xiaochaihu Decoction treating different diseases with same method from an “immune-inflammation” point of view.The differential genes about SLE and GN were obtained from GEO database,then the protein-protein interaction network map was constructed by String database and the core targets were obtained based on Cytoscape 3.8.0,then the core target data were uploaded to the traditional Chinese medicine (TCM) efficacy prediction platform for the purpose of constructing the disease network.The disturbance scores of disease network of marketed western medicine for clinical treatment of SLE and GN and Xiaochaihu Decoction was compared based on the TCM efficacy prediction platform and z-Score model.GO analysis and KEGG analysis were performed on the targets of Xiaochaihu Decoction treating SLE,GN,and targets which is shared between them by using the ClueGo in Cytoscape 3.8.0.The 95 core targets about SLE and 112 core targets about GN,82 targets of Xiaochaihu Decoction treating SLE,77 targets of Xiaochaihu Decoction treating GN and 38 core targets which is shared between Xiaochaihu Decoction treating SLE and GN were obtained according to the above conditions.According the GO and KEGG analysis,the mechanism of Xiaochaihu Decoction treating different diseases with same method may be achieved by participating in type I interferon signaling pathway,negative regulation of viral processes,response to interferon-gamma,regulation of B cell proliferation and other immune inflammation-related biological processes and mediating cytosolic DNA sensing pathway,NOD-like receptor signaling pathway,hepatitis C and other signaling pathways.It is concluded that Xiaochaihu Decoction can treat SLE and GN through pathways related to immune process and inflammatory response,a reference for further study of Xiaochaihu Decoction treating SLE and GN is provided from this article,and can be helpful in accurately locate the disease process of Xiaochaihu Decoction treating different diseases with same method.