天然产物研究与开发 ›› 2023, Vol. 35 ›› Issue (2): 342-352.doi: 10.16333/j.1001-6880.2023.2.018

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不同生境来源杂色曲霉次级代谢产物研究进展

吴宇圳,张慧敏,安芳芳,郑永标*   

  1. 福建师范大学生命科学学院,福州 350117
  • 出版日期:2023-02-28 发布日期:2023-03-02
  • 基金资助:
    福建省自然科学基金面上项目(2020J01172);厦门医学院海洋生物医药资源福建省高校应用技术工程中心开放课题(MBS-201902);福建师范大学生命科学学院溪源江学者创新项目(2019)

Research progress on secondary metabolites of Aspergillus versicolor from different habitats

WU Yu-zhen,ZHANG Hui-min,AN Fang-fang,ZHENG Yong-biao*   

  1. College of Life Sciences,Fujian Normal University,Fuzhou 350117,China
  • Online:2023-02-28 Published:2023-03-02

摘要:

杂色曲霉是曲霉属的常见种类,广泛分布于海洋、高等植物、红树林和节肢动物等生境中,近年研究表明杂色曲霉可产生生物碱、萜类、聚酮等结构多样的次级代谢产物,具有抗菌、抗肿瘤、抗氧化、抗病毒等活性。本文总结了2017—2022年间报道的37株杂色曲霉次级代谢产物结构及其生物活性的研究进展,涉及325个次级代谢产物,其中新化合物111个。本文揭示了杂色曲霉的次级代谢产物与生境的相关性,对从更多生境来源的杂色曲霉及其它微生物资源来挖掘新天然产物具有参考作用。

关键词: 杂色曲霉, 生境, 次级代谢产物

Abstract:

Aspergillus versicolor is a common species of the Aspergillus genus,which widely distributed in marine,higher plants,mangroves,arthropods,and other habitats.Recent studies showed that A. versicolor could produce alkaloids,terpenoids,polyketides and other structurally diverse secondary metabolites that possessed antibacterial,anti-tumor,antioxidant,anti-virus,and other activities.This paper summarized the research progress on the structure and biological activity of secondary metabolites isolated from 37 strains of A. versicolor in 2017 to 2022,involving 325 secondary metabolites,111 of which were new compounds.This paper revealed that the secondary metabolites of A. versicolor had a close relationship with their habitats.It will shed some light on digging new natural products by using more strains of A. versicolor and other microorganisms from different habitats.

Key words: Aspergillus versicolor, habitat's, secondary metabolites

中图分类号:  R284.1