天然产物研究与开发 ›› 2025, Vol. 37 ›› Issue (11): 2035-2039.doi: 10.16333/j.1001-6880.2025.11.007 cstr: 32307.14.1001-6880.2025.11.007

• 研究简报 • 上一篇    下一篇

深海真菌Penicillium sp. SZWQM-1中的2个新化合物

薛俊娟1*，王雷清1，李  波1，崔玉磊2   

  1. 1山东中医药高等专科学校中药系，烟台 264199；2临沂大学医学院，临沂 276000
  • 出版日期:2025-11-27 发布日期:2025-11-26
  • 基金资助:
    国家自然科学基金(82204762)；山东省中医药科技发展计划(2020M037)；国家中医药管理局科技司-山东省卫生健康委员会共建中医药科技项目(GZY-KJS-SD-2023-051)

Two new compounds from the deep-sea-derived fungus Penicillium sp. SZWQM-1

XUE Jun-juan1*,WANG Lei-qing 1,LI Bo1,CUI Yu-lei2   

  1. 1Department of Traditional Chinese Medicine,Shandong College of Traditional Chinese Medicine,Yantai 264199,China;2School of Medicine,Linyi University,Linyi 276000,China
  • Online:2025-11-27 Published:2025-11-26

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摘要：

为了研究深海真菌Penicillium sp. SZWQM-1的化学成分，采用多种柱色谱技术对其发酵产物进行分离纯化，通过核磁共振波谱、质谱、红外光谱等方法鉴定化合物结构，并采用DPPH自由基清除实验对分离得到的化合物进行了体外抗氧化活性测试。从Penicillium sp. SZWQM-1的乙酸乙酯提取物中共分离得到了7个化合物，分别为penithol（1）、penithochromone U（2）、penithochromone R（3）、penithochromone A（4）、penithochromone P（5）、penithochromone J（6）、penithochromone K（7）。其中化合物1和2为新化合物，分别命名为penithol和penithochromone U。活性实验结果显示，化合物1和3在1 mmol/L下DPPH自由基清除率为55.9%和40.9%，表明化合物1和3对DPPH自由基具有中等程度的清除能力。

关键词: 深海真菌, Penicillium sp. SZWQM-1, 化学成分, 色酮, 抗氧化

Abstract:

In order to investigate the chemical components of ethyl acetate extracts from the deep-sea fungus Penicillium sp. SZWQM-1, compounds were isolated and purified using various column chromatography techniques, and their structures were identified by NMR, MS, and IR methods. The in vitro antioxidant activity of the isolated compounds 1-7 was assessed using the DPPH scavenging methods. Seven compounds were isolated from the EtOAc extract of Penicillium sp. SZWQM-1, including penithol (1), penithochromone U (2), penithochromone R (3), penithochromone A (4), penithochromone P (5), penithochromone J (6), penithochromone K (7), of which compounds 1 and 2 were new compounds, named penithol and penithochromone U, respectively. The results of the activity experiment showed that compounds 1 and 3 had DPPH free radical scavenging rates of 55.9% and 40.9% at a concentration of 1 mmol/L, indicating that compounds 1 and 3 have moderate scavenging abilities against DPPH free radicals.

Key words: deep-sea-derived fungus, Penicillium sp.SZWQM-1, chemical composition, xanthone, antioxidant

中图分类号:  R284.2

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