关键词: 银杏黄酮, 非酒精性脂肪性肝病, 核因子-&kappa, B

Abstract: In this study,the effect of Ginkgo Flavone on nonalcoholic fatty liver disease (NAFLD) in mice was investigated,and the correlation between NF-κB and the level of hepatic steatosis or serum ALT was analyzed.170 KM mice were randomly divided into 5 groups:control group,model group,high ［300 mg/(kg·d)］,medium ［150 mg/(kg·d)］ and low ［75 mg/(kg·d)］ dosage of Ginkgo Flavone groups.High fat diet was used to establish the animal model.The pathological changes of liver,liver index,the serum TC,ALT,TNF-α and NF-κB in hepatic tissue were observed after 4,8 and 12 weeks of administration.Compared with the model group:the level of liver index,serum TC,ALT,TNF-α and the expression of NF-κBp65 in the Ginkgo Flavone groups were dramatically decreased.The hepatic steatosis was milder (P<0.05 or P<0.01).The correlation analysis showed that the NF-κBp65 in hepatic tissue was positively correlated with the hepatic steatosis and the serum ALT (r>0, P<0.01 or P<0.05).These results showed that Ginkgo Flavone can decrease the serum lipid and hepatic steatosis,improve the index of liver function and liver histolomorph in the time and dosage dependent manner.NF-κB related pathway might be the main mechanism of the effect.

Key words: Ginkgo Flavone;non-alcoholic fatty liver disease;nuclear factor-&kappa, B